If you're paying full price for Ozempic, Wegovy, Mounjaro, or Zepbound, you're likely spending $900 to $1,350 per month. But the GLP-1 pricing landscape has changed dramatically in 2026 — there are now more ways to save than ever before, and many people are overpaying simply because they don't know about all the options.
We've compared every major pricing pathway side by side, with real numbers. Here's what you need to know.
The Complete Cost Comparison
| Option | Monthly Cost | Medications Available | Best For |
|---|---|---|---|
| Manufacturer Savings Card | $0 – $25/mo | Brand Ozempic, Wegovy, Mounjaro, Zepbound | Commercially insured patients |
| TrumpRx Program | $245/mo | Select brand-name GLP-1s | Uninsured or high-deductible plans |
| LillyDirect | $349/mo | Zepbound only | Cash-pay Zepbound users |
| Telehealth + Compounded | $199 – $399/mo | Compounded semaglutide/tirzepatide | Budget-conscious, flexible on brand |
| Medicare (New Apr 2026) | $50/mo max | Brand GLP-1s for qualifying members | Medicare beneficiaries with obesity + comorbidities |
| Employer Insurance | $25 – $150/mo | Varies by plan | Employees at companies that cover GLP-1s |
| Full Retail (No Savings) | $900 – $1,350/mo | All brand-name | Nobody — always look for savings first |
Option 1: Manufacturer Savings Cards (Potentially $0/month)
Both Novo Nordisk and Eli Lilly offer savings programs that can dramatically reduce your cost — sometimes to zero. These are the first thing to check before exploring any other option.
Eli Lilly's savings card for Zepbound can bring your copay to as little as $25/month if you have commercial insurance. Novo Nordisk's program for Wegovy offers similar savings. The catch: you must have commercial insurance (not Medicare/Medicaid), and your insurance must cover the medication — the savings card just reduces your out-of-pocket copay.
Pros
- Lowest possible cost
- Brand-name medication
- Easy to activate at pharmacy
Cons
- Requires commercial insurance coverage
- May expire annually
- Not available for Medicare/Medicaid
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Check Eligibility →Option 2: TrumpRx Direct-to-Consumer Program ($245/month)
The TrumpRx program launched as a way to provide direct-to-consumer access to certain prescription medications at negotiated prices. For GLP-1s, the price point is $245/month — significantly less than retail but more than some telehealth alternatives.
The key advantage is that this provides brand-name medications without insurance. The program has specific enrollment requirements and is still being rolled out, so availability may vary by region.
Important: The TrumpRx program is still evolving. Check current availability and eligible medications directly through the program's official channels. Pricing and terms may change.
Option 3: LillyDirect ($349/month for Zepbound)
Eli Lilly's direct-to-patient platform cuts out the middlemen. You get genuine, brand-name Zepbound shipped directly from Lilly at $349/month — no insurance needed. This includes a telehealth consultation for the prescription.
Pros
- Guaranteed brand-name Zepbound
- Direct from manufacturer
- Includes telehealth consultation
Cons
- Zepbound only (no semaglutide options)
- $349/mo is still significant
- No insurance billing option
Get Price Drop Alerts
GLP-1 pricing changes constantly. We'll notify you when new savings programs launch or prices drop.
Option 4: Telehealth Platforms + Compounded GLP-1s ($199-$399/month)
This has become one of the most popular options for people paying out of pocket. Platforms like Hims & Hers, Ro, Found, and Calibrate offer compounded versions of semaglutide and tirzepatide at significantly lower prices than brand-name medications.
| Platform | Monthly Price | What's Included |
|---|---|---|
| Hims & Hers | $199/mo | Compounded semaglutide, telehealth visits, ongoing monitoring |
| Ro | $249/mo | Compounded semaglutide, body composition program, metabolic labs |
| Found | $249 – $399/mo | Multiple medication options, nutrition coaching, ongoing support |
| Calibrate | $349/mo | Brand-name preferred, metabolic reset program, 1-on-1 coaching |
Compare Telehealth Platforms
See which platform offers the best value for your specific needs.
Compare All Platforms →Note on compounded medications: Compounded GLP-1s are not FDA-approved and are produced by compounding pharmacies. The FDA has issued guidance on this market. While many patients report positive results, it's important to discuss with your healthcare provider. Regulatory changes could affect availability.
Option 5: Medicare Coverage (New — $50/month max)
This is a game-changer for the 65+ population. Starting April 2026, Medicare covers GLP-1 medications for members with obesity and qualifying comorbidities. The copay is capped at $50/month through the new demonstration program — making it one of the most affordable pathways available.
Approximately 10% of Medicare beneficiaries will qualify based on specific health criteria. If you're on Medicare and have a BMI ≥30 (or ≥27 with related health conditions), talk to your doctor about enrollment.
The Decision Framework
Here's the simplest way to figure out your best option:
If you have commercial insurance: Check manufacturer savings cards first. If your plan covers GLP-1s, you could pay as little as $0-25/month.
If you're on Medicare: The new April 2026 coverage at $50/month is likely your best bet if you qualify.
If you're uninsured or your insurance won't cover it: Compare TrumpRx ($245), Hims ($199), and LillyDirect ($349). Your choice depends on whether you want brand-name vs. compounded and which medication you prefer.
If cost is your #1 priority: Telehealth platforms offering compounded semaglutide at $199/month are currently the lowest-cost option for most cash-pay patients.
Don't Overpay for Your GLP-1
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